Uterine fibroid undergoes secondary changes like
• Calcareous degeneration.
• Red degeneration.
• Sarcomatous change.
Atrophy: Occurs after menopause and delivery. The fibroid gradually reduces in size due to diminished blood supply.
Calcareous degeneration: Along the course of blood vessels which supply to the fibroids have calcium and phosphate of lime deposition from periphery. It is seen in old women who have long standing myoma.
Red degeneration: The most emergency complication of uterine fibroid is red degeneration. The myoma becomes tense and tender with purple rd color and a fishy odor. It is found due to thrombosis of the small blood vessels which supply to the myoma. The exact phenomenon is not described yet.
Sarcomatous change: It is rare change of uterine fibroid. 0.5% of myoma undergoes Sarcomatous change. It is rare for the malignant transformation of uterine fibroid in women under the age of 40 years.